I've linked to Jen Campbell (otherwise known as aeroplanegirl on twitter) and her blog many times now. Among other things, she brought us the hilarious "Weird Things Customers Say in Bookshops" series, which is soon to be published as a book.
Jen has a condition called EEC Syndrome, which causes gradual blindness in those affected by it. You can read about her experience of it here. She is fundraising for research into degenerative eye conditions in a very cool way - writing 100 poems over the course of one weekend in November - and you can sponsor her at this link.
This is a cause that could radically change the lives of many many people, but it's hardly well-known, or sexy, as charitable causes go. Why not support research in a new and interesting way and support Jen's poetry with as small or large a donation as you can muster?